DEVELOPMENT OF QUATERNIZED AND CROOSLINKED MICROPARTICLES OF QUITOSANE TO THE DEOXYRIBONUCLEIC ACID (AND) ADSORTION

  • José L. Cconislla Bello
  • Christian Jacinto
  • Ily Maza
  • Martha Jahuira
  • Alejandra Pando
  • Holger Mayta
  • Ana Valderrama
DOI: https://doi.org/10.37761/rsqp.v82i4.136
Keywords: quaternization, crosslinking, quitosane, DNA

Abstract

The crosslinked quitosane microparticles (QE1%, QE5%) were prepared by reticulation with glutaraldehyde (GL). The quaternized quitosane microparticles(QC) were prepared by quaternization of the quitosane amine group with glycidyl trimethyl ammonium (CTAG). The microparticles were characterized and subjected to adsortion tests. To characterization of quitosane microparticles different techniques were used like FTIR spectroscopy, DRX, TGA, DTG and SEM. The DNA quantity adsorbe in the microparticles was determined by uv-visible spectroscopy in a NanoDrop2000 equipment getting very encouraging results. The Langmuir and Freundlich adsortion models were applied to describe the balance isotherms. The Freundlich model adapts with the experimental data.

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Author Biographies

José L. Cconislla Bello

Faculty of Sciences, School of Chemistry, National University of Engineering, Av. Túpac Amaru 210, Rímac Lima 25, Peru.

Christian Jacinto

Infectious Diseases Research Laboratory, Department of Cellular and Molecular Sciences, Faculty of Science and Philosophy, Cayetano Heredia Peruvian University.

Published
2016-12-31
Issue
Vol. 82 No. 4 (2016): Journal of Sociedad Química Del Perú
Section
Artículos

Copyright (c) 2016 Sociedad Química del Perú

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