XANTHONES FROM Hypericum laricifolium Juss., AND THEIR ANTIPROLIFERATIVE ACTIVITY AGAINST HEP3B CELLS

  • Marlon Miguel Morales Moisela
  • Orianne Brel
  • Geneviève Bourdy
  • Mercedes Gonzales de La Cruz
  • Inés Yolanda Castro Dionicio
  • Maelle Carraz
  • Valérie Jullian
DOI: https://doi.org/10.37761/rsqp.v84i4.63
Keywords: Xanthones, Hypericum laricifolium, Hep3B cells, hepatocellular carcinoma

Abstract

We describe here the isolation of 6 xanthones and one phenyl-γ-pyrone, together with 3-epibetulinic and quercetine from the aerial parts of Hypericum laricifolium Juss. (Hypericaceae), collected in Peru. Isolated compounds have been evaluated against proliferation of human hepatocellular carcinoma Hep3B cells. The most active compound was xanthone 3, with an inhibitory concentration (IC50) of 12 µM.

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Author Biographies

Marlon Miguel Morales Moisela

Ricardo Palma University, Benavides Av. 5440, Santiago de Surco, Lima 33, Peru.

Orianne Brel

UMR 152 Pharmadev, Université de Toulouse, IRD, UPS, France

Geneviève Bourdy

UMR 152 Pharmadev, Université de Toulouse, IRD, UPS, France.

Mercedes Gonzales de La Cruz

Ricardo Palma University, Benavides Av. 5440, Santiago de Surco, Lima 33, Peru.

Inés Yolanda Castro Dionicio

UMR 152 Pharmadev, Université de Toulouse, IRD, UPS, France.

Research and Development Laboratories, Universidad Peruana Cayetano Heredia (UPCH), Lima 34, Peru.

Maelle Carraz

UMR 152 Pharmadev, Université de Toulouse, IRD, UPS, France.

Valérie Jullian

UMR 152 Pharmadev, University of Toulouse, IRD, UPS, France.

Research and Development Laboratories, Universidad Peruana Cayetano Heredia (UPCH), Lima 34, Peru.

UMR 152 Pharmadev, University of Toulouse, IRD, UPS, Faculté de Pharmacie, 35
Chemin des Maraichers, 31062 Toulouse Cedex 09, France.

Published
2018-12-31
Issue
Vol. 84 No. 4 (2018): Journal of Sociedad Química Del Perú
Section
Artículos

Copyright (c) 2018 Sociedad Química del Perú

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